Description
- Zortex is an important product that inhibits bacterial sortase due to its direct antibacterial activity toward toxigenic Clostridium perfringens that enable it to bypass the multifactorial mechanisms of resistance of Clostridium perfringens
- Zortex eliminates Clostridium perfringens through prevention of its ability to grow by decreasing pH, as Clostridium perfringens is a pH sensitive bacterium which cannot tolerate a pH less than 5.2 ± 0.1
- Zortex reduces the inflammatory response through the inactivation of NF-κB signaling pathway in intestinal epithelial cells challenged by Clostridium perfringens, as the main cell wall component of Clostridium perfringens is peptidoglycan (PGN) which is recognized by TLR2.2 or NOD1 in chicken intestinal epithelial cells, and thereby activating the NF-κB signaling pathway
- Zortex adsorbs Clostridial toxins and prevents them from entering the systemic blood circulation which leads to reduction of their negative impact on performance and production of poultry
- Zortex promotes restoration of the intestinal microflora by countering effects of intestinal damage caused by Clostridium perfringens through the inhibition of its overgrowth
- Zortex stimulates the gut-associated lymphoid tissue through increase in small intestinal lymphoid nodule count which supports and maintains intestinal immunity against harmful pathogenic bacteria such as Clostridium perfringens, E. coli and Salmonella
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